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viral replicase complexes, which perform viral RNA replication. We find that Sac1 affects the recruitment of other host factors, enrichment of phosphatidylethanolamine and sterol lipids within the subverted host membranes to promote optimal viral replication. In summary, this work demonstrates the novel functions of Sac1 and PI (4)P in TBSV replication in the model host yeast and in plants. Copyright © 2020 American Society for Microbiology.HPV16 E7 has long been noted to stabilize the TP53 tumor suppressor. However, the molecular mechan
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