https://www.selleckchem.com/pr....oducts/3,4-dichlorop
We observed that ABCD4 was able to transport cobalamin from the inside to the outside of liposomes dependent on its ATPase activity, and that LMBD1 exhibited no cobalamin transport activity. These results suggest that ABCD4 may be capable of transporting cobalamin from the lysosomal lumen to the cytosol. Furthermore, we examined a series of ABCD4 missense mutations to understand how these alterations impair cobalamin transport. Our findings give insight into the molecular mechanism of cobalamin transport by whi
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