https://www.selleckchem.com/pr....oducts/nibr-ltsi.htm
Splicing factor 1 (SF1) is a conserved alternative splicing factor expressed in many different mammalian cell types. The genetically modified (or ) mice express reduced levels of SF1 protein in mouse tissues, including in cells of the intestines. Mutational inactivation of human adenomatous polyposis coli (APC) gene deregulates the signaling pathway and is a frequent genetic event in colon cancers. Mice with a point mutation in the gene ( ) also develop numerous intestinal polyps at a young age. Our aim was to determine the effect of
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