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There are various artificial markers in ultrasound images of thyroid nodules, which have impact on subsequent processing and computer-aided diagnosis. The purpose of this study was to develop an approach to automatically remove artifacts and restore ultrasound images of thyroid nodules. Fifty ultrasound images with manually induced artifacts were selected from publicly available and self-collected datasets. A combined approach was developed which consisted of two steps, artifacts detection and removal of the detected artifacts. Specifi