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INTRODUCTION The consumption of substances is a common practice among the medical students and their use might reduce educational and clinical performances as well as judgment of the students. This study aims to find out the prevalence of substance use among medical students in BP Koirala Institute of Health Sciences. METHODS A descriptive cross-sectional study was carried out among medical students of BP Koirala Institute of Health Sciences from 15th September 15th to December 15th 2018 after obtaining ethical approval from the Instituti