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Suppression of key signaling particles managing metabolic and proliferative occasions, such as for instance Akt, P70S6K and NF-kB, ended up being observed. Increased expression of caspase-3 proposes the possibility pro-apoptotic effect of curcumin within the imatinib-resistant CML design. Extra in silico molecular docking scientific studies revealed binding modes and affinities of curcumin with different targets plus the results are according to in vitro conclusions. Completely, these outcomes indicate the potential