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How Does ADHD Medication Work? Many people discover that ADHD medications can help them concentrate, focus and control their impulse-driven behavior. But it can take time to determine the appropriate medication and dose for each person. Certain medications can affect children's sleeping patterns. If they are sleeping better, it is a good sign that the medication is working. 1. Stimulants The most common prescription medication used by healthcare professionals to treat ADHD is stimulants. They increase the levels of certain chemicals (neurotransmitters) in your br