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erein the quantitative bias measured in malignant lesions (hot spots) decreased from - 12.3 ± 2.3% when using the Gaussian filter to - 3.5 ± 1.3% and - 2.2 ± 1.2% when using the NLM and MR-NLM approaches (p value 0.05), respectively. The MR-NLM approach exhibited promising performance in terms of noise suppression and signal preservation for PET images, thus translating into higher SNR compared to the conventional NLM approach. Despite the promising performance of the MR-NLM approach, the additional computational burden owing to the