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We conclude that skeletal muscles should be considered as a key organ system in exertional heat stroke pathophysiology.This study aimed to assess whether obesity and/or maximal exercise can change 24 h cardiac autonomic modulation and blood pressure in young men. Thirty-nine men (n 20; 21.9±1.8 kg·m-2, and n 19; 32.9±2.4 kg·m-2) were randomly assigned to perform a control (non-exercise) and an experimental day exercise (after maximal incremental test). Cardiac autonomic modulation was evaluated through frequency domain heart rate variab