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OBJECTIVES The aim of this study was to investigate the effect of virtual patient-based training on the clinical decision-making ability of dental students. METHODS This quasi-experimental study with pretest and posttest design was conducted on 76 (2015 admitted) dental students of Shiraz Dental School in 2018-2019. The study samples were randomly divided into 2 groups intervention (web-based virtual patient training = 36) and control (face-to-face case-based training, n = 4. The data collection tools in this study included a question