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However, in EBV-related cHL cases, a higher number of PDL1 + cells were detected at the microenvironment. Even though a high cytotoxic environment was previously described in EBV-related pediatric cHL, it might be counterbalanced by an immunoregulatory micro-environmental PDL1 + niche. This regulation may render a cytotoxic milieu that unsuccessfully try to eliminate EBV + Hodgkin Reed Sternberg tumor cells in pediatric patients. Even though a high cytotoxic environment was previously described in EBV-related pediatric cHL, it might be c