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43). After adjustment for heart rate, highlogDPPI was associated with all-cause mortality [hazard ratio 1.67, 95% confidence interval (1.55-1.81) per SD; P less then 0.001], cardiovascular mortality [hazard ratio 1.95 (1.72-2.22); P less then 0.001], and incident heart failure with reduced ejection fraction [hazard ratio 1.81 (1.60-2.06); P less then 0.001]. These associations remained independent upon further adjustment for confounders. Optimal cutoff values for DPPI ranged between 6.1 and 6.3 m/s for all endpoints. After multiv