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This article highlights the importance of exploring multiple sterilization modalities during the product development stage to support sustainable business continuity plans. There are ever increasing researches implying that noncoded RNAs (ncRNAs) specifically circular RNAs (circRNAs) and microRNAs (miRNAs) in exosomes play vital roles in respiratory disease. However, the detailed mechanisms persist to be unclear in mycobacterial infection. In order to detect circRNAs and miRNAs expression pattern and potential biological f