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The applications of artificial intelligence, and in particular automatic learning or "machine learning" (ML), constitute both a challenge and a great opportunity in numerous scientific, technical, and clinical disciplines. Specific applications in the study of multiple sclerosis (MS) have been no exception, and constitute an area of increasing interest in recent years. We present a systematic review of the application of ML algorithms in MS. We used the PubMed search engine, which allows free access to the MEDLINE medical database, to i