https://www.selleckchem.com/pr....oducts/Cisplatin.htm
Systemic mastocytosis (SM) is a rare myeloid neoplasm driven in ≈95% of cases by activating mutations, usually D816V. SM can be indolent (ISM), smoldering (SSM) and advanced (AdvSM), the latter characterized by organ damage resulting from infiltrating neoplastic mast cells. The vast majority of cases are indolent, with near-normal life expectancy, although symptoms can be severe. AdvSM, comprising aggressive SM, SM with an associated hematologic neoplasm and mast cell leukemia, however, carries a poor prognosis. Avapritinib is a highl
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