https://www.selleckchem.com/
Further, phosphorylation of the mitogen-activated protein kinase (MAPK) p38 was enhanced, and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) was decreased in cells infected with LdHSP78+/- compared to wildtype (WT) infection. Virulence of the LdHSP78+/- strain was restored by episomal addition of LdHSP78 gene. Finally, using high-throughput virtual screening, we identified P1,P5-di(adenosine-5'-penta-phosphate ammonium salt (Ap5A) as an LdHSP78 inhibitor. It selectively induced amastigote death at doses similar to amphotericin B (AmB
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