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The initially readily available SARS-CoV-2 isolates require version in order to utilize the mouse angiotensin converting enzyme 2 (mACE-2) entry receptor also to productively infect the cells associated with murine respiratory tract. We now have "mouse-adapted" SARS-CoV-2 by serial passaging a clinical virus isolate in the lungs of mice. We then used reasonable doses for this virus in mouse designs for higher level age, diabetes and obesity. Just like SARS-CoV-2 disease in humans, the results of i
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