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CONCLUSION Our results indicate macrophage polarization instability as a crucial procedure underlying the damaged angiogenesis and bone tissue healing in diabetes, and supply sitagliptin as a promising book drug for biomaterial-engineering to improve the osteointegration of titanium implants in diabetics. Myocardial fibrosis (MF) plays a vital part within the development and development of heart failure (HF) with limited effective treatments. Galectin-