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Medications and Therapy For ADHD Combining medication and therapy can help to manage ADHD. Medicines treat the brain while therapy helps individuals develop techniques and manage. The stimulants like methylphenidate and Lisdexamfetamine boost the levels of two chemical substances that transmit messages between cells in the brain. This can increase the rate of attention and impulse control. The stimulants can cause adverse effects, including difficulty sleeping, decreased appetite, and increased blood press