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Parts of the testes were subjected to histopathological and electron microscopic examination. The carvedilol/alpha-lipoic acid combination restored the food intake, testicular weight and functions, sperm characteristics, hormonal profile and the antioxidant defences compared to the use of each of these drugs alone. Also, this combination significantly ameliorated inflammation (P less then .05) and induced significant increase in tissue Nrf2/HO-1 content (P less then .05) and significant improvement of the histopathological and electron
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