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A 21-indicators list and its 8-indicators brief version were also proposed as indicators of psychosocial complexity. We present a definition of psychosocial complexity in cancer patients that has been agreed by experts, also establishing its four factors medical-physical, social-family, psychological, and spiritual. This has led to the development of a list of indicators (and its brief version) that, after a validation process, could help health professionals to identify patients with high psychosocial complexity to provide them an opt