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The Most Effective ADHD Medication For Adults Stimulants are the first-choice medication for adults with ADHD. They help regulate levels of two chemical messages within the brain that regulate attention. The is Strattera (atomoxetine). It is a pill or oral capsule that can be taken either with or without food. It is suitable for the majority of people. It lasts longer than stimulants that have an action time that is shorter like amphetamine or methylphen