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Acute gastroenteritis is a common childhood disease with substantial medical and indirect costs, mostly because of referral, hospitalization and parental absence from work. To determine the cost-effectiveness of adding oral ondansetron to care-as-usual for children with acute gastroenteritis in out-of-hours primary care. A pragmatic randomised controlled trial at three out-of-hours primary care centres, with a follow-up of 7 days. Inclusion criteria were 1) age 6 months to 6 years; 2) diagnosis of acute gastroenteritis; 3) at least four