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Methylation analysis revealed that hypermethylation of the RORγ promoter was associated with the colon cancer stage. RORγ downregulation could be a potential biomarker for colon cancer, especially for predicting prognosis. Decreased RORγ expression in colon tumor may be associated with promoter hypermethylation. RORγ downregulation could be a potential biomarker for colon cancer, especially for predicting prognosis. Decreased RORγ expression in colon tumor may be associated with promoter hypermethylation.Secondary organizing pneumonia (SO