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All rights reserved.Peste des petits ruminants (PPR) is a severe, very contagious and fatal viral illness of little ruminants causing large financial losses. Therefore, the illness had been targeted for eradication by 2030. The purpose of this study was to research the very first time the molecular and pathological characterization regarding the circulating PPR virus (PPRV) in sheep and goat in Palestine. Samples were collected from suspected necropsy cases of sheep and goats during current outbreak