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Serum anti-double-stranded DNA antibody titers in SHR-A3 were elevated compared with SHR-B2 and had been reduced in SHR-A3(Stim1-B2). Conclusions Stim1 deficiency in lymphocyte function originating from Stim1 truncation in SHR-A3 mixes with hypertension to generate end organ infection and can even achieve this due to antibody formation.Purpose To describe the employment and 1-year outcomes of retrograde pedal access during peripheral vascular interventions (PVI) for chronic limb-threatening ischemia