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Here, we review these computational methods in the context of enhancer prediction and gene regulatory network models specifying cell fate. Expected final online publication date for the Annual Review of Genomics and Human Genetics, Volume 21 is August 31, 2020. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Positive airway pressure (PAP) associated claustrophobia is common among obstructive sleep apnea patients and plays a prominent role in low adherence and treatment failure. As there are