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Objective The objective of this study is to evaluate fatigue in cancer outpatients receiving chemotherapy using an objective system and to clarify the type of nursing support needed after a disaster. Methods Based on the diagnostic criteria for chronic fatigue syndrome, the degree of subjective fatigue, autonomic function, and amount of physical activity were measured in cancer outpatients undergoing chemotherapy from an area affected by the Great East Japan Earthquake. Results The study participants were ten adults (8 men [80.0%] and 2