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This novel ES-framework provides cross-disciplinary methods to prioritize urban areas where greenspace interventions can have the most impact based on heat-related demand.Amphotericin B (Am is an effective drug to treat visceral leishmaniasis but its use is limited by its poor oral bioavailability. This article describes the in-vivo evaluation of AmB-loaded, lipid-based cochleate systems designed for the oral route. Two different cochleate formulations were studied one based on the synthetic phospholipid dioleoylphosphatidylserine (DO