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The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we studied the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells, showing that the doxorubicin resistance of MDA-MB-231/ADM cells was much higher than MDA-MB-231 cells. And the gene or protein expression of XIST and ANLN were higher in MDA-MB-231/ADM cells than that in MDA-MB-231 cells.
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