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What is the topic of this review? This manuscript provides a review of the current understanding of the role of the sympathetic nervous system in regulation of the bone marrow-derived immune cells and their involvement in hypertension. What advances does it highlight? We highlight the recent advances in understanding of the neuro-immune interactions both peripherally and centrally as they relate to blood pressure control. The sympathetic nervous system (SNS) plays a crucial role in maintaining physiological homeostasis in part by regulat