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05). Group B also had higher levels of IgA, IgG, and IgM than group A after intervention ( 0.05). Group B had higher levels of FEV1, PEF, and FVC than group A after intervention ( 0.05). In contrast to group A, group B had lower IL-4 levels and higher TNF-γ levels ( 0.05). The incidence rate of adverse events in group B was not significantly different from that in group A ( 0.05). Systemic care combined with 2HRZE/4HR was effective for treatment of primary tuberculosis, which is beneficial for improving the immunity,