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Regardless of COVID-19 origin, studying the evolution of the molecular mechanisms involved in the emergence of pandemic viruses is essential to develop therapeutic and vaccine strategies and to prevent future zoonoses. This article is a translation and update of a French article published in Médecine/Sciences, August/September 2020 (10.1051/medsci/2020123). The online version of this article (10.1007/s10311-020-01151-1) contains supplementary material, which is available to authorized users. The online version of this article (10.1007/s1