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MT2A (metallothionein 2A) is the most important isoform of metallothionein (MTs) in individual and large appearance of MT2A in tumors signifies poor prognosis and metastatic behavior. Nonetheless, there are no reports concerning the molecular method of ESD when you look at the regulation of cyst metastasis. In this study, we discovered for the first time that activation ESD presented its discussion with MT2A and decreased the necessary protein level of MT2A, which causing t