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Pulmonary FDG uptakes were positively correlated with the ILD severity (fibrosis extent, %FVC, and %D ). No significant difference was found in the FDG uptakes from extrathoracic ROIs. Progressing SSc-ILDs within the 2 years after PET/CT (n = 9) had significant higher pulmonary FDG uptakes at baseline than stable SSc-ILDs (n = 13). PET/CT could be a useful tool in the assessment of the severity and the prediction of pulmonary function outcome of SSc-ILD. PET/CT could be a useful tool in the assessment of the severity and the prediction