https://www.selleckchem.com/products/cc-92480.html
In 2006, humans with a congenital insensitivity to pain (CIP) were found to lack functional NaV 1.7 channels. In the subsequent 15 years there was a rush to develop selective inhibitors of NaV 1.7 channels with the goal of producing broadly effective analgesics without the problems of addiction and tolerance associated with opioids. Pharmacologically, this mission has been highly successful, leading to a number of highly potent and selective inhibitors of NaV 1.7 channels. However, there are very few examples where these inhibitors hav
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