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Tuberculosis, a major global health concern, and its drug development toward the disease are too devastating to meet the clinical demands. The present work emphasizes a detailed QSAR study using QSARINS which developed descriptors favoring an excellent model equation. The best model equation generated has four variables namely AlogP, ATSc4, mindssC, and MDEC23 with statistical values R2 = 0.7406, LOF = 0.1858, CCCtr = 0.8510, Q2LOO = 0.6569, Q2LMO = 0.6286, CCCcv = 0.8037, R2ext = 0.8600, and CCCext = 0.9252. The developed QSAR model j
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