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The purpose of this paper is to prospectively evaluate the performance of an artificial intelligence (AI) system in diagnosing thyroid nodules and to assess its potential value in comparison with the performance of radiologists with different levels of experience, as well as the factors affecting its diagnostic accuracy. In recent years, medical imaging diagnosis using AI has become a popular topic in clinical application research. This study aimed to evaluate the performance of an AI system in diagnosing thyroid nodules and compare it w