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Of note, serum sCD40 was not associated with progression to lung metastasis. Circulating sCD40 is a marker of liver metastasis risk in rectal cancer and may be developed for use in clinical practice. Circulating sCD40 is a marker of liver metastasis risk in rectal cancer and may be developed for use in clinical practice. Folate, vitamin B6 and vitamin B12 have been associated with digestive system cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. Two, one and 14 independent s