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Then, the ssDNA changes into a G-quadruplex comformation, which brings the labeled FAM and TAMRA into close proximity, leading to a stronger FRET sign. Into the absence of UDG, the fairly steady dsDNA distinguishes the labeled FAM and TAMRA, offering a weak FRET sign. Therefore, by measuring the device fluorescence intensity and exploiting FRET sign huge difference, UDG activity is detected in a simple process. The detection limitation is 0.087 U/mL without calling for additional signal amplificatio