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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD treatment, since they are the most researched and have the fastest-acting effects. But they aren't right for everyone. These medications boost signaling between nerves and the regions of the brain to reduce symptoms of ADHD. These medications can also trigger adverse effects such as a change in blood pressure or heart rate as well as an increase in appetite. Stimulants Stimulants are among the most commonly used drugs used to treat ADHD. They