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Aims This study investigated effects of narrow-range ultraviolet irradiation (UVR) by a new UV-LED device on vitamin D supply and changes of bone in senescence-accelerated mouse P6 (SAMP6) with vitamin D deficiency. Main methods We used female SAMP6 mice as a senile osteoporotic model. We set a total of 3 groups (n = 4 per group); D-UVR+ group (vitamin D deficient-dietary and UVR), D- (vitamin D deficient-dietary), and D+ groups (vitamin D contained-dietary). Mice in the D-UVR + group were UV-irradiated (305nm) with 1 kJ/m2 twice a week