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In addition, we explore the reasons why young people tend to engage in both behaviors, and consider future research directions and clinical implications. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] human intermediate conductance calcium-activated potassium channel, KCa3.1, is involved in several pathophysiological conditions playing a critical role in cell secretory machinery and calcium signalling. The recent cryo-EM analysis provides new insights for understanding the modulatio