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Conclusions These ERP results are consistent with the Noisy Operator Theory - suggesting that an age-related increase in internal noise affected letter-matching performance. Gram-negative bacterial infections represent still a severe problem of human health care, regarding the increase in multi-resistance against classical antibiotics and the lack of newly developed antimicrobials. For the fight against these germs, anti-infective agents must overcome and/or bind to the Gram-negative outer membrane consisting of a lipopolysaccharide (LP