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Single-atom site catalysts (SASCs) are characterized with atomically dispersed isolated metal active sites and theoretically 100% metal dispersion. Supports with high specific surface area are crucial for the fabrication of highly efficient SASCs with maximized metal dispersion. The high specific surface area supports provide anchoring sites that stabilize the monodispersed active metal atoms. The metal atoms and their coordination environment jointly constitute the metal single-atom sites, which represent the active sites of SASCs. The s