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Using these reference periods, 63 puppies with ionised hypercalcaemia were identified, of which 23 did not have complete hypercalcaemia. Only seven associated with 23 puppies with ionised hypercalcaemia and total calcium underneath the upper limitation for the reference period had hypoalbuminemia. Nearly all dogs with ionised hypercalcemia and typical total calcium had a modest rise in ionised calcium. MEDICAL SIGNIFICANCE If depending on total calcium alone, more than one third of