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Proteomic data revealed a breast milk-induced molecular pattern associated with tissue remodeling and homeostasis. Using a novel ex vivo pediatric enteroid model, we have identified distinct cellular and molecular events involved in human milk-mediated improvement of human intestinal physiology and immunity.Unlike adult cancers that frequently result from the accumulation in time of mutational "hits" often linked to lifestyle, childhood cancers are emerging as diseases of dysregulated development through massive epigenetic alterations.