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3 cell cultures . In summary, the results show that rtPA may be poisonous to neural cells and that OGD exacerbates poisoning, while R18D has the capacity to lower rtPA neural cellular toxicity and lower MMP-9 activation in astrocytes and bEnd.3. Poly-arginine-18 peptides, which are being developed as neuroprotective therapeutics for ischaemic swing, consequently have actually the extra potential of lowering cytotoxic impacts involving rtPA thrombolysis in