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003). Such linear-like behavior was not observed for dilutions peak internalization occurred with the 30cH dilution, accompanied by cellular degeneration, and IL-6 and IL-10 increased ( ≤ 0.05) only in the cells treated with 6cH. and presented different patterns of potency-dependent effect on macrophage activity. Bacterial digestion and a balanced IL-6/IL-10 production were related to 6cH, though reduced oxidative stress with increased lysosomal activity was related to 200cH. Degenerative effects were exclusively related to 30cH, and potency-dependent ph