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The best surgical option to treat drooling in neurodisabilities is still under debate. The aim of this study was to describe the technique of subtotal functional sialoadenectomy (SFS) (ie four-duct ligation (4-DL) together with bilateral sublingual gland excision) and its long-term outcomes, in comparison with 4-DL. Retrospective observational cohort study. Unit of Pediatric Surgery of Bambino Gesù Children's Hospital (Rome). Seventy-five patients surgically treated for drooling between 2002 and 2012, with at least five years of follow-up